Walterboro isn't a major city in SC (I was born in Yemassee, about 15 minutes away), but I'm sure the Best Western, although I've never stayed, is OK. I wish I had that drive from MD instead of NJ...that ride to Florida would be a breeze. We wing it from here to FL, no hotel stays on the way down.
Is that the one with the indoor pool? If so, yes. It was a decent hotel room. Pretty regular, but we picked it so the children we were traveling with could get some excercise after the long trip.