A very full Locker is one that is more time-consuming to pack. That's a BIG reason I just added a THIRD Locker!
As for what to put in the third Locker, what about clothes? I keep several sets of clothes for each of us - that eases the packing burden. I also keep a sweatshirt, which is bulky but also usually needed for me in the evenings knocking around the villa. We can just travel carry-on now! Or we can check our luggage, but have small pieces of luggage to lug...we don't pay extra fees for luggage since we fly Southwest.
Here's my list, which isn't updated since I added the 3rd Locker in late June, so there's new stuff in storage that I don't have anywhere except on my paper copy. Must get that done before our next trip in 36 days!
Airborne to Go packets
I don't think this stuff works, but my DH does, so I don't mess with his belief system 
Alex's sunglasses
Alex's toothpaste
Alka Seltzer (36)
Almay eye makeup remover pads
Aluminum foil
aluminum water bottles (2)
antibacterial gel
antibiotic pain relief ointment
antiseptic foam
Apple Airport Express no being tethered to the wall, and my husband can use his Touch instead of bringing a laptop
baby powder
Bandaid blister pads (12)
battery charger and rechargeable batteries
BC powder
benedryl
benedryl/itch cream
Bisquik shake & pour
blister stick
Blue Ice blanket
bobby pins
body lotion
body wash (Joe)
Brita filters
Brita pitcher No spending money on bottled water! Cheaper and better for the environment! Some people put their filter in a ziplock and store it to use the next time, but I worry about mold, so I don't. I put a new filter in when we arrive, then put that filter in a ziploc and bring it home to use so that I'm not wasting it.
candles (12 tealights)
chapstick
chick peas
chicken breast chunks (foil pkg)
chip clips
coffee grinder my husband loves his fresh ground coffee - makes him much less grumpy in the morning!
collapsible colander
combs
Connect 4 mini game
contact lens case
cotton pads
cough drops - honey lemon (40)
crayons
Crystal Light packs
cumin
Curly Sexy Hair - curl activator
Curly Sexy Hair - spray mousse
Cutex remover pads
dental floss
deodorant - Joe
deodorant - Tara
Disney Scene It this is the travel size - we always play one night - it takes up very little space, too
disposable razors
Dove cloths (5pk)
Downy packs
Dr.Bonners small bottle
ear plugs (foam and silicone for swimming)
emery boards
excedrin
extra outfit - Alex (khaki shorts, blue/green polo)
extra outfit - Joe (khaki shorts, blue polo)
eyeglass cleaner
Fashion Emergency Kit
Febreze to Go
fleece blanket this was a "spend $30 and get blanket for $10" deal and it's great for warding off chills when the a/c is too much for me but just right for everyone else - I LOVE having this and use it pretty much every day
fleece gloves for cool weather stays, a pair of gloves can make all the difference for night touring
garlic salt
glitter Tinkerbell sometimes comes to visit us and leaves a trail of pixie dust Oh! and our son lost a tooth at Disney in May and Tinkerbell helped the tooth fairy find him
Gold Bond powder (1oz)
Gorillapod
grape jelly packages
griddle my son LOVES pancakes and I can make more at once this way
hair clips
hair dryer with diffuser the Disney ones take a long time to dry my hair
hairspray
hand sanitizer
Hidden Mickeys book
Hot Hands warmers
Hungry Jack syrup
hydrocortisone cream
Ibuprofen (100)
ice cream scoop
ice trays
Imagineers Guide - Epcot
Imagineers Guide - Magic Kingdom
Immodium
inflatable bath pillow
iPhone/USB cable
Kids shampoo
kitchen knife a good Henkels all-purpose knife - the ones in the units are often so dull
lemon pepper tuna (foil pkg - 2)
LifeSavers (pepp-o-mint)
lighted Mickey toy
lint roller
Listerine - 20oz
magnetic clips
Markers
matches
Mickey learn-to-draw
Mickey coffee scoop
Mickey dish towels
Mickey madras plaid dress
(I'd never wear it outside Disney anyway)
Mickey madras sundress
Mickey measuring cups
Mickey measuring spoons
Mickey pancake turner
Mickey pizza cutter
microfiber towel
microwave popcorn (3 pk)
mini A1
mini Grey Poupon
mini mayo
mini umbrellas
misters (not fans)
Motrin Jr. chewables
mouthwash
nail clippers
Nesquik
Neutrogena face wash - Joe
Old Navy anorak (
folds into its own front pocket, DH likes to wear this for an extra layer on cooler days)
Orbit gum 3 pack
Pal Mickey
Pam spray
pancake turner
peach schnapps (1/3 full)
Pepto caplets (40)
phone charger - Joe
pink butterfly PJ bottoms - Tara
pins & lanyards
plates
playing cards
poncho - adult
poncho - child
ponytail holders
pop-up hamper
q-tips
Quik Pod this is a handheld, extendable camera mount that we can use to take our own pictures when no one else is around to ask or we don't feel like asking. Works great and in situations where the GorillaPod won't
razor
razor blades (Joe)
rechargable batteries
refried beans
rubber spatula
running shoes - Tara
only for running, not for parks, but not having to pack the sneakers is awesome
running skirt - Tara
running tank - Tara
safety pins
sandwich keeper
scissors OMG, the most used thing in our locker
Scrapbook for DVC trips I
keep an album and photo corners and for each trip as owners we're writing in it so we'll have a record of where we stayed, what we did that trip, etc. For our May trip (our first in the album) I put in a Photopass print we bought at the parks.
Sephora 5- makeup brush travel set
shaving cream
Shout stain stick
sketch book
my son's favorite activity is to sit and draw. We always have a small notebook and pencils wherever we are as he'll happily draw while waiting in long lines, waiting for food, etc.
slippers - Tara
small cutting board
small tray for cards this is something I picked up at Mousegears - it's a great spot to deposit room keys, APs, etc so they're always in one place
Star Wars DVDs we ended up with an extra set, so we stored one - keeps my son well occupied during rainy afternoons, quiet time when a nap isn't going to happen, etc.
Sucrets (18)
Sudafed PE (72)
sunglasses - Alex
super glue
this came in handy in May when my son's new Star Wars toy broke
surge protector
swim coverup (American Eagle dress)
swim shirt - Alex
swimsuit - Alex
swimsuit, Alex (5T) -
yes, there are 2
swimsuit, Joe
tampons
tea (Lapsang Souchong)
my husband's favorite, plus he swears they use it to make the "Rome burning" smell in Spaceship Earth
tea ball
Tide (17 loads remaining)
Tide individual boxes (2)
Tide liquid packs
Tide to Go
tomato paste (small can)
toothbrushes - Tara/Joe
Tostitos salsa
Tums (24)
tweezers
tylenol chewables
underwear - Alex (5pr)
underwear - Joe (4pr)
Vaseline
vegetable peeler
Wall-E Learn-to-Draw
water bottle holders (3)
water lock box
WDW coloring book
WDW sticker book
WDW temporary tattoos
Wet Wipes
whisk
white washcloths
Ziploc gallon
Ziploc quart