The PVSA looks at where a passenger embarks a ship and where the same passenger debarks the ship in making it's determinations.
So, your B2B would be a NY to Miami cruise. You can't sail from one US port to a different US port without a stop in a DISTANT foreign port. A distant foreign port, to the PVSA, is any port NOT "in North America, Central America, the Bermuda Islands, or the West Indies (including the Bahama Islands, but not including the Leeward Islands of the Netherlands Antilles, i.e., Aruba, Bonaire, and Curacao)".
Antigua (West Indies) is considered part of North America, so doesn't qualify as a distant foreign port.
To answer the question - yes, there are people who have experienced this before (check out the Alaska repo cruises in 2012 to see what happened there).