w/o kids start at IOA be there before opening go directly to Hulk ride 2X then Spiderman, then River Adventure, then Fire and Ice. After that, you can double back and ride Ripsaw falls and Bluto's Bilge Rats if you want to get wet or head out and go to US. At US get fast-pass (can't remember what they call them at Universal) for Mummy and get in line for Shrek, then work your way around the lake seeing/doing whatever looks good. I personally dont like the Back to the Future ride, long lines and rough ride. Use single rider lines if possible at Mummy, Men In Black they will save a ton of time if you dont mind not being with your party during the ride.
W/ young kids we do the same thing, only stop and ride One fish and Cat in the Hat at IOA. We also go to the Barney show, play area and ET at US. If some of your party dont like the big rides, send the younger ones with them and have them go directly to the Suess area and let them go wild.