We have driven from the Akron-Canton area many times...don't let the thought overwhelm you...it's a pretty easy drive. You didn't say how you wanted to break up the trip time-wise, so I will tell you what we have done.
We sometimes leave in the evening and drive about 5-6 hours stopping in Beckley, WV (Microtel was a clean, cheap place to stay), Princeton, WV or Hillsville, VA. All of these stops were safe, cheap places to stay. Then the next day, we drove the rest of the way arriving about check-in time....
Other times, we leave early and make it a long day, stopping at Pooler, GA (plenty of places to sleep), Brunswick, GA (Sleep Inn was clean and cheap) and we have driven as far as Palm Coast, FL (that was too long!). We always leave knowing where we are stopping. You can usually get the cheapest rate by booking ahead and it gives you a goal (destination) for the day. We arrive at WDW by lunch time and have most of the day to enjoy.
Some tips with kids...have each child pack an activity bag. Buy ahead of time something new for their bags and give it to them after you leave. Pack lots of snacks (take things they don't get all the time) but limit liquids to minimize the "potty stops". When you do stop, let the kids use the bathroom first, giving them time to expend some energy outside while the parents take turns using the bathroom. It takes a little longer but the kids will be happier. Let them each take a small blanket and pillow...let them stay up late the night before leaving. They will sleep in the car which allows longer stretches of driving. Allow the kids to switch seats in the car after stops...believe it or not, it works to break up the trip.
Driving can be fun...yes, it takes longer but if you think of it as part of the vacation instead of the drudgery to get to vacation then it makes it easier to handle. I hope this helps!