Touristy stuff like zoos, aquariums, amusement parks, etc. Good restaurants and child friendly micro brews with games....places to sit and talk and hang out.
Back to San Diego:
The San Diego Zoo
The San Diego Zoo Safari Park
Balboa Park (has 20-ish small museums with some being free) ** This was not a huge deal for me as I have some of the greatest museums in my backyard so kind of underwhelmed here but other people love it.
USS Midway Tour
Lots of various boat tours on the bay.
La Jolla Cove - See the seal and sea lions, take a kayaking tour in the cove. Have lunch or dinner at Duke's (one of my faves)
Whale Watching Tours
Coronado Island - beautiful beach, free roam through the Hotel Del Coronado
Oceanside and Oceanside Pier - one of the longest walkable piers on the West Coast
Cabrillo National Monument
Mount Soledad Veteran's Monument
Sea World is in San Diego
Take the Surfliner from San Diego up to Anaheim for a day or two in Disney if you want a Disney fix
Easy to take a beach day here and there. Most of the beaches have public access and public parking with bathrooms.
San Diego has tons of breweries and is quite the foodie spot for very casual dining. Love hitting the various mom and pop taco shops.
I've stayed at a few hotels there and I think, as a tourist, I liked being in the Downtown/Bayside/Seaport Village area. The Marriott Residence Inn Downtown Bayfront has one of the best free breakfasts I've had in the various hotels (aside from the Embassy Suites). Very clean, courteous staff. It shares the building with Springhill Suites. But all the Residence Inn rooms have in-room kitchens, which is a must for me.