We stayed there with a manual wheelchair. I loved that the resort was so small though pushing a manual chair over the cobblestone made it a bit tougher. I'm assuming you'll feel the bumps as you drive over the cobblestone. Most areas you can go on the sidewalks which are smooth so it's only crossing the "streets" where you'd feel the cobblestone, if that's even an issue for you.
We had no problems anywhere at the resort. Everything was easily accessible.
I loved that even when sharing busses with POR (didn't happen often), POFQ was always picked up first. I remember feeling really bad for some people at POR who couldn't get on the bus because the tie down spots were all taken already.