We drive from central Indiana and LOVE it. DH loves to drive, and even after driving all day every day for work (he's an Orkin route manager), he still has no qualms about driving 1100 miles to FL. Our first two Florida vacations were beach trips, and we stopped in Macon GA both times. The girls were little, 1 & 2 the first time, 2 & 3 the second, and we had an in car DVD player to keep them entertained.
Last year we picked them up from school on the last day, and drove straight through to Ft Myers Beach. 22 hours, NO in car DVD player or DS in sight. um, no CD player either.

I did have my iPod loaded up with music, and they slept most of the night. I had a laptop with Verizon wifi which worked out great until it got really dark and the lit screen bothered DH while driving. He drove the first 11-12 hours, and I took over at Valdosta GA and drove the rest of the way. Coming home we also did straight through, leaving at 10am Saturday and got home at 6am Sunday. It was rough, but we easily saved $200 by not stopping.
When we drive to WDW next month (yay!!!) we're leaving late on a Saturday afternoon and hope to be at SoG by noon on Sunday. Plan is to spend that day lounging and swimming, then resort hop to shop, eat a QS dinner, and get settled into our rooms. My parents are leaving that Saturday morning, and they'll stop for the night, but they are also in their late 60s and Mom can't sit in the car for hours and hours on end. I plan to have activity bags for the girls, books, and some cool podcasts on my iPhone. DH and I have Kindles for reading while the other is driving, and I can sleep pretty well in the car. We LOVE driving and can't imagine ever flying!