I'm from the Grand Rapids area and we always end up taking 65 south and love that way. Maybe it's because we have driven it 9 times out of the last 8 years, but most of those times was to visit my parents in Alabama. The only part we don't like is Atlanta and always try to not hit that during rush hour.
We always drive straight thru and yes, the kids stay buckled, but the last couple times when we rented a minivan my DH reclined the seats a little so they weren't sitting straight up. My kids have gotten better sleeping at night in vehicles, but they still try to stay awake as long as they can because they are afraid they might miss something. I keep telling them the only thing they will miss is Semi's here and there.. and to go to sleep. They do love seeing the bigger cities at night.