The section from Beckley, WV to Wytheville, VA is kind of hilly. The WV portion is more winding. If you leave early in the morning, it should be light when you go through. It is about six hours into the drive before you get into this section. It is a interstate so the roads are two lanes in each direction. Gas prices in WV always seem more expensive. I try to fill up in Marietta and then wait until VA to fill up again. Also try to avoid going through Charlotte from 4-6 PM. During rush hour it can back up. When staying overnight, I always try to stay on the side of town that I would be driving in the opposite direction of the morning rush hour traffic. That really only applies if you leave your hotel during the morning rush hour. VERY IMPORTANT: Have a roll of quarters and some singles in your car in case you end up on one the toll roads near WDW. I ended up on one using my GPS to get to the grocery store from our hotel.