Timely question, as I'm currently relaxing at a hotel in preparation for tomorrow's flight to New Orleans! I ALWAYS unpack. I can't stand to be pawing thru bags and backpacks, trying to find what I want. Currently, although my main suitcase is still packed and in the car, I unpacked my overnight bag. Jammies, tomorrow's clothes, and my "spare in case we get stranded" clothes are in a drawer, toiletries either on my nightstand or in the bathroom. Everything's lined up and orderly, and I can relax.