We have a Garmin and she is called Gabby Sue, no particular reason, it's just what DH started calling her. We talk back to her, make fun of her, generally anything to make our many, many road trips fun!
For instance when we plug in a destination that we know a short cut for, we still have her (yes we call our Garmin her) on, when we make a turn that she (of course) thinks is wrong, we say 'yes, we know Gabby Sue we're going the wrong way". Then we have fun seeing how long it takes 'her' to find the route we're taking instead of trying to redirect us back to what 'her' original route was.