If you go when there's no traffic from Disney the drive is probably just under an hour.With some traffic 1 hr 15 minutes.Take I-4 west to Tampa,when you get to I-75 take it north for like 4 miles,get off at exit 265(Fowler ave.)take that west for a couple of miles,you'll pass MOSI on your left and the University 0f South Florida on your right,pretty much as you see the main entrance of USF on your right you'll turn left onto Mckinley which will lead you to the entrance!!