I love my class C, bought because, with my bad back, I needed to be able to get up stretch, etc, on long trips (yes, occasionally without a seatbelt, sorry). Love the fact that I can play board games on the dining room table with DS, make sandwiches for lunch, etc, while tooling down the road (DH driving, in that case, obviously!). Overhead bed is nice and large, and couch folded down is comfortable (dinette only big enough for short person!). The only big drawback is not having a vehicle once at destination (we don't have a toad), but have rented one if needed (in SD Black Hills, for example).
Advantage of 5th wheel, obviously, is having a vehicle once you get to your destination, but it does need to be comfortable enough to travel in (which can drive the price of the tow vehicle into the 40K range, easy).
Love our C!
Terri