Add me to the "look at Michigan again" chorus. I'm on the faculty there, have had season tickets for about 25 years, and both of my kids are alumni. It's a pretty phenomenal experience. Get there early enough to see the drumline's step show,
march to the stadium with the band, and stay at least through the third->fourth quarter break to get the full experience. 107K+ people
singing Mr. Brightside a capella is a thing.
Flights are easy, though can be expensive on Delta (it is a DL hub). Tickets will be available--there are north of 107K of them--but they may cost a bit. The good news is that unlike some years, there are several big-draw games on the home schedule (Texas, USC, Oregon, and MSU), which might spread out demand a bit among the "one game a year" crowd. If you do not have mobility issues, parking in town as
@mgarbowski recommends is a very good idea. Conscessions at the stadium leave a lot to be desired. For a night game, eat dinner in town before going down. For an earlier kick, eat after the game in town while traffic subsides.
One warning: those late September games can be deceptively hot, especially if it is a noon kick. Wear sunscreen and drink lots of water. Game time will depend on which network has first pick that weekend, because whoever it is will probably take USC @ Mich as the headliner for that week. The other compelling B10 home games on that slate are ILL @ Neb, Iowa @ Minn, and NW @ Wash. OSU has a cupcake, but they always draw well on TV, so they may be in the mix too. And I'm pretty sure the Washington game won't be the "noon" (EDT) kick.
If you don't do Michigan, I'd pick Minnesota as the next best game day experience, but that's just based on reputation/seeing the crowd on a broadcast. I haven't been to either Minnesota or Maryland, but Minnesota's new stadium looks very nice.