Of course this is all the preference of the driver, some like Interstates , some don't mind US routes. We just moved to central FL from IL, and to avoid the mountains in Chattanooga while hauling a trailer, we opted for the Alabama - Florida panhandle route as shown on the google map. After you get to Montgomery it's all US route that takes you through several small towns, some pretty congested, depending on the time of day you're there. Then when you FINALLY get to the FL panhandle it takes FOREVER to get to I - 75. If I were to do this again I would head east on I-20 @ Birmingham over to Georgia (Bypass Atlanta on I -285) to I-75. I'm sure it's more miles, but at least your muvin. Plenty of nice motels along the way too. Have fun!