It is very seldom that I order photo items from anyone other than B&H. Here in the Boston area, their standard shipping, which I get free being a NAPP member, usually gets it to me overnight. Their prices are competitive. And, they can be a great source for non-photo items as well. As for their Friday evening through Saturday evening closure, it is no big deal and I applaud them for standing up for their beliefs. Many places close for a day or two or have limited hours one day a week so you just have to deal with it. If they allowed orders when they are closed, people would start complaining that they didn't get their shipments on time, so it is best for everyone that they don't accept orders.
If you ever go to NY, a trip to their store is a real treat. Don't buy there as you will have to pay NY sales taxes, but it is an incredibly efficient operation and fun to see, especially the overhead stock bins flying around.