I stayed at the Ayres in Anaheim last June. It was very nice and comfortable. Great bed, very clean bathroom, large tub. Really good breakfast. There is some noise from the freeway on that side of the hotel but the view is prettier from that side.
I used the Orange County Transit System, not ART, because I needed to go to Buena Park. It was very convenient. I've read that ART is very convenient there as well.
There are several good places to eat around there because of the baseball stadium and another sport/entertainment venue.
I'd stay there again if I got a good rate.