Our favorite places to vacation at the beach are the Outer Banks in NC and Hilton Head in SC. We usually vacation with our family in a rental home for a week. NC waters are colder with more waves and riptides and Hilton Head waters are warm and calm. The Outer Banks provides active lifestyle oriented activities and historical places to visit (ie Wright Brothers, Roanoke) and Hilton Head is more upscale, quiet but lots of golf and restaurants. We love both and both areas provide lots of hotels, condos and houses for rent.
There's lots of information on a lot of the beach areas on threads here if you search and people are a great wealth of info. You might want to post what kinds of activities and experiences you want to have to give people a better idea of what you would like.
Other than a house, our FAVORITE place in Hilton Head is Marriott's Surf Watch...they are villas where you can cook your meals if you want to relax and not go out and just the perfect resort set up for relaxation. Not inexpensive, but if you stay put at the resort and enjoy, worth every penny if you don't need a whole big house.
Have fun planning and enjoy wherever you may choose!