Yes & No.
Trader Joe's, Kroger, & Winco do a great job of spreading out extra stock to fill products that are missing. So things don't look like they are missing, yet are. Lots of product foward facing on the shelves with emptiness behind.
Walmart & Target, things are straight up gone/missing/empty. To be expected due to the fact they tend to be cheaper overall when it comes to cleaning products/paper goods/some food items. Even more so with online grocery where if a product isn't in stock, they substitue pulling from the next closest product which has an impact on that product's inventory as well.
Things I've noticed that are hard to get just recently: Vitamin D milk, Plant based Milk ( was none when I looked), Individual serving size of juice boxes/bottles, Pasture Raised Eggs, Paper Towels, Meat specifically Beef. Due to the drought and wildfires, green onions, cilantro, lettuce quality have been poor.