We have never driven from Indy recently. But, years ago, when I was in high school(I obviously, I was not married yet) my parents took us me and my brother and sister to Disney. We drove STRAIGHT THROUGH to Orlando with no stopping overnight. Let me tell you, after all these years, I still remember that trip!!! By the time we got there, I remember how tired we all were, and our first day was a blur!!! All I wanted to do when I got there was sleep!! I think it took my parents like 20 hours. So, now that I have a family of my own(two DS 9 and 5 and a DH), we fly. We flew in June to Disney and it was so worth it(even with all the security now). At that time gas prices were reaching $3.00 a gallon, and I figured with that and the fact that we would want to stop overnight there and on the way back, the price was not much less than flying for the four of us. If you want to drive, I would seriously consider breaking up the trip into 2 days going there and coming back. On the other hand, keep an eye on airfares. Southwest and Airtran both fly out of Indy and their fares are great sometimes! We flew the four of us last summer for just over $700 total(about $178 round trip per person). So, don't think I helped you out at all, but good luck in your decision!!! You have to make the best decision for your famiy reguardless of what everyone says.