Another couple of votes for Cranium, and Scene It .
Three of my other favorites are:
Flashback - it's a game about 70's, 80's and 90's sitcoms
True Colors - it sounds kind of like Loaded Questions (i'll have to get that one). You are given descriptions of people and have to vote/guess who in the room is most like the description.
Zobmondo - You are given a choice between two things. A this or that kind of game. They have a regular version and and a raunchy version (I have the raunchy version, of course..some gross out questions of which you'd rather).
I love board games...can't get enough of them.