I have a mixed amblyopia and strabismus as a result of problems during birth.
As a child i was patched from the age of 4. As an adult I now attend the binocular vision dept of my local University.
My spectacles contain prisms which have been split across both lenses in order to avoid a coke bottle effect.
My dominant eye can reach 20:20 with the right lens, but my weak eye gets nowhere near this level of acuity, even with specs I cant see what i am typing at the moment. This is beause when I was born, my bad eye did not focus the light onto my real fovea and so it atrophied and the part of my retina that did get the image will never be as good as a fovea as there arent enough light receptors. So I kind of have a 12 megapixel left eye and a 2 megapixel right eye.
The only problems that I have had during life have been in relation to binocular vision during high speed accuracy sports such as tennis, squash, table tennis, cricket, rounders. Seeing a fast moving ball and being able to determine where it is in 3 dimentions is a real challenge for me and so I always avoided this type of team sports at school and University.
I have no problems with depth of field if the object is stationary or large (like a truck, thank goodness!!!)