We drove from Reading (northwest of Phila) Friday night before Thanksgiving and planned on driving overnight to avoid traffic. We left around 4:30pm, I think. We had a number of stops along the way- first to visit an elderly grandparent and for dinner at McDonald's and filled up the gas tank (see notes below). We drove "straight-through", stopping at the first rest area in each state to use the restroom and stretch.
DH drove the whole way down, so we had to stop in NC for him to sleep for a few hours. It was cool to see the sun wake up the morning sky

. We stopped at South of the Border to fill the gas tank again and we also stopped for lunch in Savannah, GA. We hit Florida and detoured over to St. Augustine for about an hour to tour the lighthouse and shop for last minute supplies at Kmart. We hit a pile of traffic in Orlando (football game), and that held us up for nearly an hour.
Some notes:
Spring City, PA stop for gas 5:16pm
Delaware Turnpike 7:19pm
Fort McHenry Tunnel (I-95, MD) 8:21pm
Richmond, VA for gas (also heaviest traffic since it's a metro area)
Raliegh ?, NC stopped for few hours to nap 1:30am-5:30am (I think

)
*DH couldn't stay awake any onger and I had not slept (I was too excited (and nervous) to sleep

South of the Border (NC/SC) 9:49am
* SC is the longest leg of the journey IMO
Savannah, GA 12:12pm
southern GA for gas 2:33pm
St. Augustine Lighthouse, FL 3:46pm
St. Augustine Kmart 4:26pm
Disney's ASMovies Resort sometime between 6-7pm
Total time from home to resort was over 24 hours, less stops- about 18 total drive time. A fellow coworker of mine does the same trip nearly every spring to Sanford (an hour east of Orlando) and it takes her 17 hours from the Pottstown area.
Good Luck and safe driving
