I can certainly see that Up wasn't a movie for you but I've not (knock on wood) been through what you have this year and, if it makes a difference (and if I am not out of line) my reaction was the same as yours. I couldn't get over the opening and the rest of the movie, while cute at times, was still about "what might have been," not something I wanted to be reminded about at this stage of my life. I'm lucky not to have regrets but at the same time, feel I have a lot of life left to go.
I resigned myself to thinking the movie was probably made for substantially younger, or older, folks.