During the week you'll be travelling with the worst of the rush hour traffic. The only way to make that halfway palatable is to make sure you have 2 people in your car so you can take the carpool lane for the length of the 105 freeway. To get there from DL you'd go north on the 5, west on the 91, then north on the 605 for just a mile, then west on the 105. That will take you all the way to LAX, and if you're in the carpool lane you'll be passing lots of solo drivers in slow-and-go traffic.
If you do this on a Saturday or Sunday it's not so bad. Same directions as above, but maybe you wouldn't need the carpool lane.