I've used the anti-perspirant in the past and have always had great luck. Unfortunately, this past May, my luck changed. The weather was much hotter and more humid than past visits and the spray was not enough. By the end of the first night, only 1 hour into E-night, my feet were in really bad shape. I should have skipped E-night and rested my feet, but I didn't and I paid for it. I was down for 2 days, unable to walk as the blisters that covered the bottoms of my 2 smallest toes were completely open. It was horrible. After 2 days of rest, I went for the moleskin, which worked well. On our next trip, I plan to go with spray, moleskin and thick socks all together. By the way, be sure to apply the moleskin BEFORE you spray, else it will not stick.