Having recently finished getting mastery signs for all the recipes for my FarmVille spa, this is coming at a great time for me. While I could pursue higher level masteries for recipes, or go back to doing some regular co-ops, or for that matter pursuing mastery signs for more crops, I think it might be a good time to start with a new game, from the beginning, and this one looks like it won't be as dark as Mafia Wars, as farsical as FrontierVille, or as simplistic as Treasure Island.
The only thing I'm not terribly happy about, with CityVille, is that rumors indicate that is heavily energy-based (like Mafia Wars, FrontierVille, and Treasure Island). However, I think it remains to be seen whether that's the case: After all, FarmVille is conceptually energy-based, as well, at the start, while you're so thoroughly dependent on coin.
"Commerce and Franchises" sound like FV crafting cottages and co-ops, on steroids. That's great, because imho those crafting cottage co-ops, specifically, were the best part of FV.
Please post back to this thread if you're invited into the beta, if you're allowed to, and let us know how the game looks. Thanks!