If you have a car, by far the easiest way is to drive.
Second easiest (and most expensive) is to take a taxi.
With Disney transportation, there is no direct bus transportation between resorts that are not on the same bus line, so you would need to go to a transfer point. This is harder at an Epcot resort because you can't use Epcot as a transfer point unless you want to walk through the park. Therefore it is easier to use Studios as a transfer point. From there you can take the boat or walk to the Yacht Club. Either way will take a bit of time.