I have always liked the Luxor. I have been to Vegas many many times, and was married there, to boot (at Bellagio). I have probably stayed at the Luxor the most times. I have stayed at all levels of hotels, including Luxor, Bellagio, Paris, Aladdin (now Planet Hollywood), and the Hilton Convention Center.
Of all the hotels listed, my favorite was Aladdin. The location is great (central to the strip), the option to not walk through the casino to get to a cab is nice, but if you walk to the strip, the casino is not that large, so that walk isn't bad either! then there are the Desert Passage shops right there for shopping, entertainment, and restaurants. I obviously can't speak to the decor or the service since the changeover to Planet Hollywood, but the things I liked about the hotel had to do with layout and proximity, and that hasn't changed.
I agree that where you stay on the strip (North, Center, South) doens't matter as much thanks to the monorail. But it helps to stay at a hotel that is close to a monorail station, or at least on the same side of the strip. A "block" in Vegas is a LONG walk.
I like gambling at Paris the best. We are not big gamblers, you see. Our favorite thing is to plop down at a poker slot machine, let the drinks come while we enjoy the sounds of the house music. Paris has a lovely lighting scheme, and their bands are just wonderfully entertaining! As for staying there, we felt the hike back to the hotel elevators from the strip was enough to make us disinterested in staying there again.
Bottom line: it's hard to go wrong with the "popular" hotels. It's really up to how you like to spend your time.