Although there are a few airlines I like best (southwest being one), all the "big guys" are about the same in my opinion. Customer service is not their strong suit, but they tend to have better prices and they "get the job done"--get me from point A to point B.
I have had one DREADFUL experience that bordered on dangerous with US Air and VOWED I would never fly them again, but 1 year ago I was forced to travel with them for reasons outside of my control. The experience was fine and had no problems. Since then I've flown with them 3 more times without incident.
We are going to Disney in Jan--flying USAir--the prices were the best and since I have some good experiences, I've decided to continue to give them my business.
Hope this is helpful.