I took a taxi from John Wayne to the Marriott (770 W. Convention Way in Anaheim), and it ended up being almost $50.
I took an Uber from the Marriott to John Wayne, and it was less than $25. So yes, I highly recommend taking Uber.
Otherwise, my boyfriend took a shuttle from the airport to the hotel, and he only paid $10. So if you're okay with an Anaheim resort shuttle, that's probably your cheapest option.