As an American who frequently visits Toronto, I can say that the best way to make the Toronto Airport hotel experience a great part of your vacation is to stay at either the Airport Marriott or the Sheraton in Terminal 3 with the Wyndham Bristol Place rated a distant 3rd by me.
These hotels are the two most comfortable (and $$$) on the Airport Strip...BUT the good news is that by staying on a Friday or Saturday nite you'll pay less than half the weekday rates. Example: corporate rate at Airport Marriott Sun-Thu is $249 Cdn, but wknd rates are around $119 Cdn.
The Marriott in particular is my favorite for it's great breakfast buffet (ask for the "Two for Brkfst" rate on the wknd), great indoor pool, wonderfully service-oriented staff who really care, and a very comfy feel to all parts of the hotel...and you earn Marriott Reward points.
Many of the other hotels on the Airport Strip seem to have a stark, "cold" feel to them (e.g Hilton, Holiday Inn, Radisson Suites, Regal Constellation, Quality Suites....I wouldn't bother with). I was shocked last year when I stayed at the Radisson Suites and was charged for a shuttle bus ride to/from the airport....I am a very seasoned traveller and no where else in North America have I ever experienced this!
Have a great trip!