We recently drove from CT. We left at 3:30 pm. on Friday, got stuck in some traffic around NYC for about an hour, but from there it was clear sailing all the way. We grabbed some dinner on the Garden State Parkway at a Burger King around 5:30 and went straight through until 6:30 a.m. the next morning when we stopped in SC about 50 miles north of the GA border at a Cracker Barrel for breakfast. We have 3 kids (11, 8, 7), and they slept a good portion of the overnight, and watched videos, played Nintendo DS or listened to iPod during other times. We arrived in Orlando about 12:30 p.m. the next day with very little, "are we there yet" complaining. On the way back we left Orlando at 4 a.m. the following Saturday, stopped for meals and arrived back at our home in CT at midnight (20 hours). Again, very little complaining. It all depends how you entertain the children and your own stamina and patience as to whether you can do it without stopping.