We just watched it last night and as a woman who is currently TTC w/out much luck ,

I must admit I was hit hard in the first 15 minutes. I did cry for most of the movie, prompting DH to ask "Is this you or the hormones crying?"

(I get misty but I'm not a cry cryer, KWIM?)
I took it from a different perspective however. My perspective was that it was a love story of sorts. Boy falls in love with girl, they grow up and get married, she is the spark that he needed in his life, they find out that there would be no babies and they are heartbroken, but then he gives her back her "Adventure Book" to remind her that their adventure is not over!

It has taken a detour!"

They have a wonderful long life together, she passes, he wants to fufill her dream because by love it has become his too!
Another parallel is that everyone seems lost but they eventually find someone/somewhere / some heart to call home. Russel finds Carl; Carl finds Russel; Doug finds Carl; Kevin finds Russel together Russel and Carl help Kevin.
The end, although I have to tell you that I was crying so hard I thought my contacts were sure to flow out of my eyes

Carl's wife gives him the same gift her gave her so many years befor, it was greatest gift of all by showing him how he added to her life. . . her adventure, no regrets.
So you see, it's all about perspective. That's mine for now. . . It may change and I have no need to watch it again anytime soon to be honest

but again it's just my opinion.
E