Yeah, I figured they would, seen as the book series is basically all about the Serena/Nate/Blair thing...
But they probably won't follow the books until about the time they're ready to end it.
Blair has to be a bit more understanding towards Chuck. Chuck is kind of a monster in a way, and he isn't about to change overnight, it'll take a while. If she had given him about 10 more seconds he probably would have spit it out.