I hate other artificial sweetners, so I tried Splenda. I loved the taste and the flexibility of cooking with it. But after about 3 weeks of regular use (in my tea & in nightly desserts,) I became ill. My resting pluse dropped from my usual 80s to 42 and I felt exhausted all the time. My primary care physician thought something serious was wrong with me, so he referred me to a cardiologist & a pulmonary specialist. After a thalium stress test and 24 hours on a halter monitor, as well as a VQ lung scan, the doctors were stumped. Meanwhile, since I was sick, I was not cooking with (or eating) Splenda. Within about a week, I was back to "normal."
I contacted Splenda just to let them know about my experience and was put in touch with their medical department. I called for 3 days before I finally got through. I was always on hold for a LONG time, so maybe other people have had some health related problems as a result of using Splenda. Splenda was very nice and offered to send me a refund for the amount I paid for their product.
I now avoid Splenda, much like people with wheat or nut allergies avoid those products. But I am concerned about the fact this product is being used in foods marketed to children. I hope more research will be done. I know it's made from sugar, but by swapping three chlorine molecules for three hydrogen-oxygen groups on the sugar molecule, it really does change it's form. I mean think of the difference between H2O (water) and H2O2 (hydrogen peroxide.)