Yes, Sanford is about an hour from WDW. Sanford is right on I 4 so just hop on 4 west & watch for the signs. If you haven't been to the area recently, there are some new exits from 4 to the Disney hotels & parks so watch the signs closely.
Also be aware that all of the exit numbers along ALL of the highways in Florida have recently changed so that the exit number is now the mile marker of the road that you're on.
