Looks like it's a prescription drug.
Interesting tidbit about it: Zofran is not for preventing nausea or vomiting that is caused by factors other than cancer treatment or surgery.
Yes; Zofran is Rx only.
"Off-label" use occurs with a huge number of medications. When a drug goes through FDA approval, certain studies are cited to demonstrate its efficacy. Many other studies are typically done that are not sent to the FDA. A company can only market the drug for those uses that were evaluated by the FDA, even though there may be many other safe and effective uses of the drug. This is called "off-label" use.
Ask any pregnant woman who uses Zofran for nausea, or a mom how has a child with a stomach bug. I'm incredibly sensitive to motion sickness, and I travel with my drug cocktail.