I used to Love to Fly and actually wanted to be a flight attendant

but now I get very nervous especially since I've had kids.
However, given the alternative of 3 days in the car I much rather fly 3 hours . I usually fly at least twice a year with my most recent flight 10 days ago. What has helped me so much is a book called "Flying without Fear" by Browne--- you can probably get it from
Amazon.com.
It explains everything and give you coping techniques to use on the plane. It explains all the noises, take off, turbulence and air pockets etc. My biggest concern while flying is taking off- but the book take you through step by step so you know that after you actually take off and feel like you are falling it is actually suppose to feel that way. Its a great book.
While you are flying make sure you bring gum for the older kids and bottles for your younger one. When you take off and land pressure builds in your ears which is alleviated when you chew and swallow. A little girl on our last flight fell asleep and when she work up she had a terrible earache. But I have found that if we chew gum or suck a bottle we don't have a problem.
While you are on the plane, make sure you bring something that makes you relax. You may want to bring an ipod, hand held video game or even an audio book that will distract you to the fact that you are on a plane. A few years ago, when my flying anxiety really peaked, Song (Delta) had planes that had TV's and with the combination of the above book and the TV's flying became a breeze. I actually got so caught up in the trivia game I was playing against all the other passengers that I was so happy when they announced that Pres Bush was waiting to take off and we couldn't land until he did and we had to circle for about 20 minutes. (I was like Oh good I get one more chance to come in first)

If you don't want to take a heavy duty drug to get you thru the flight you may relax just by taking an Advil. they used to help me relax preflight too. See what works for you in everyday stressful situations. Maybe a Latte calms you or a stiff drink!!
When pilots are asked what the most dangerous part of the flight is they all response ---the trip to the Airport!! And it is true. In the last month over 1 million planes have taken off and landed safely just in the US. Over 12 million flights per year!! Yes I know its make so much sense that flying is safe but it still causes so much anxiety. (I still am afraid, but have reduced my anxiety alot) Just think of it a transportation, Just like getting on a bus at Disney and being driven to the parks. Really, we all just hop on the bus and none of us knows anything about the bus drivers accident history or health history but we all don't fret about that -- And just how many bus drivers do we trust down in Disney? Same goes for substitute bus drivers we entrust with our kids. Or how about the Tower of Terror or the RnRC.
Since you have never flown, you may find that you absolutely LOVE it. Then you can help me next year prepare for my next flight!!

GOOD LUCK!!