That route is um ...
interesting. I'm about 8 miles from Santa Monica, and have never taken the 22. I don't see Google or Yahoo suggesting it, either.
The problem I have with it is that this route
maximizes the time on the 405.
I get on I-105 after a short jaunt on the 405 South, and then there are several ways to get to DLR - involving some combination of I-5, I-605, and CA-91