I use Sanford a lot. I rent a car, it's never been a hassle. The drive is not bad at all, it makes up for it as there is not a huge wait at Security or tons of walking from one end of the airport to another for gates. I get direct flight for low cost at Sanford, security short, and the size much smaller are the gret pluses.
You could never do a taxi when it's about an hour away. I watch rates, using a tentative reservation and watch for other codes and discount prices closer to the trip. Never prepay, unless you're traveling in a few days and get a huge rate break.