I think this is one of those cases of whom is in your party -- RPR is definitely our favorite, and especially if you have smaller children. HRH has more of a happenin' vibe, I would recommend that for people with teens or young adults. We also enjoy PBH, but it has a more adult feel.
HRH is a closer walk to the Studios, RPR is a closer walk to IOA. You can also always take the boat or a pedicab, really transportation is not an issue, all the hotels are close to the attractions.
You can also pool hop at will, so if you want to get a good feel for a hotel where you are not staying, grab your suit and your room key and go on over!
Maria