I do a lot of them. I'm actually a terribly nervous flyer and while I've conquered the fear enough to fly when time or distance demand it, I'd much rather road trip most places. We did 6 weeks, MI to CA the long way around, in 2019 on our way to move DD21 into her dorm, and 3 weeks in a rented campervan in Alaska in 2021. Last year, it was a week in a campervan in Death Valley and the surrounding area for spring break. Even in Europe, we rented a car to spend a week exploring the Scottish Highlands and islands, and another for our week in Ireland to do some exploring away from the usual tourist track.
This year, I've got the mother of all road trips planned - Route 66, IL to CA, totally solo. Just me and my Jeep and my tent. I'll have company for the more direct return trip, since I'm going out for DD's graduation and dorm move-out, but I am SO excited for that outbound leg!