Sanford International Airport is approximately 50 miles from Disney. It is about an hour drive from that airport. There are no shuttles that run to Disney from there. The airport is served by car service and taxis. The taxis meter runs approximately $125.00 or slightly more depending on the resort you are going to. That is a one-way price, so double it if you want to return by taxi. DME, by contract, with the Orlando Airport does not serve the Sanford Airport, however times to Disney from either airport are the same because departing Sanford is much faster than it is in Orlando.
Car service runs about $180.00 and up for round trip service to Disney, or $100.00 one way. That is a low figure as the figure could get higher depending on the company you choose. The Sanford website lists companies who are permitted there and normally would charge the lower rates. Many Orlando companies charge higher rates because of the distance they have to travel, from Orlando, to pick you up.