I've used Priceline for airfare probably a dozen times, flying from Manchester NH, Boston, Bangor ME, Harrisburg PA, all going to Orlando. I've never had any problems, even though there might have been a weather delay, equipment problem, or overbooking. I usually end up paying 50%-75% of the published airfare, depending on location and season. What seems to be standard, though, is you will fly TO your destination on the last flight of the day and home FROM your destination on the earliest flight, so don't expect to vacation on your travel days. The best way to book a flight is to look at all the flights going from your local airports to your destination. Check prices, plane sizes, flight times, so you know what to bid and what you're willing to accept. Go to biddingfortravel.com for lots of insight on how to bid on Priceline.