I used hotwire when I went to NYC last April with DH and DS13. I definitely paid more than I would have thru priceline, but we needed 2 beds. When I got there to check in, they still had us in a room with 1 bed. IThe hotel tried telling me that all discounted rooms were for 2 people only. I even had the receipt from hotwire with 3 people listed - they just kept saying that I had to call hotwire about that. It was so frustrating. But, in the end, it worked out and they moved us.
So, my point here is that there is no guarantee that even if you book with hotwire you won't have a problem upon checkin. I'd go for the low price thru priceline and take the chance if I were you! Have fun!