I haven't played a hand in over 15 years, so my opinion of specific games may be irrelevant. Having said that, I always generally preferred the games that had the most rules. You know, some guys just love to have wild cards, hi-low splits, etc. I always felt my edge there was I could think thru the math on stuff like that a little quicker than the average bear, especially if everyone else was drinking and telling jokes (which I always strongly encouraged). So although I found basic games (5 card draw; hold em) personally more enjoyable, I found the games with more bells and whistles more profitable. Contrary to this, I always liked strictly hold-em at the poker houses, because the simpler the game the less chance there was for somebody to cheat me.
I don't know how to explain reading a room, or picking up on tells. It's just a gut instinct thing for me I guess. One thing I do recall that is poker specific... for MOST PEOPLE (got to know your opponent), when they're bluffing they hold their cards/chips tighter. This means the color of their hand will actually change. In reading a room, it is usually easy to tell whether you have everyone's attention or not, and whether they are absorbing what you are saying or letting it go in one ear and out the other. Averted eyes, sighs, etc (all the usual body language) tell you you'd better change course if you want to be effective in what you're doing in that moment.