WL is considered a deluxe. I believe there is a difference in bed size in that you have queens at the WL and only doubles at the POFQ. WL has inside corridors while POFQ are outside. WL offers sit down restauarant and more eating options -- POFQ has sit down at POR but not at POFQ. The theme is also different -- very much like the Pacific Northwest -- very nice, though. For us, after living in the Pacific Northwest for 16 years the theme wasn't attractive...it was just like being at home. Just as the Coronado Springs theme isn't attractive since we now live in the SW.
I think it depends on what you want out of your visit. If you are going to spend a little more time at the hotel then you might want to try WL. If not, then the POFQ would cost less and afford you many of the things that the WL offers. If you are going to spend more time at the MK or the area surrounding it, then the WL might be a good option. Again, it all depends on what you are looking for out of the trip. Personally, we wouldn't spend the extra for the WL ... if we were to splurge we would go for the Epcot area due to its location and we like BC/YC stormalong bay.
Either place those is nice, and after all, you will be at Disney... what more could one want?