Get Dave Hunters book Along I-75 if you plan to drive that route. It is an essential tool! It tells you what restaurants, motels, gas stations, etc are at each off ramp and also gives alots of interesting facts, tidbits about things along the way. It was very entertaining. The last time we went, we had that book as well as CAA TripTiks, but we never even looked at the Triptiks.
Our last trip we left in the evening, 6 pm, and drove through until about 1 pm the following afternoon. We stopped at a motel in Georgia, rested, swam, shopped at an outlet centre right next door and then continued the remaining 6 or 7 hours the next day and arrived in Kissimmee in the afternoon. Our son was three years old that trip, so we thought it might work out better if he slept most of the ride. When he started to get restless we stopped and got a motel room.
I think the next time l would prefer to leave in the morning and stop at suppertime and then carry on the second day. If one can sleep while one drives and then change positions, it might work out better, but I was too nervous that dh would fall asleep while driving if he didn't have someone to talk to and so we both stayed awake the whole night!